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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Virological cure 46% Improvement Relative Risk Virological cure (b) 62% Discharge and WHO-OSC>2 -67% Hospitalization -300% c19favipiravir.com/ivashchenko.html Favors favipiravir Favors control
9 August 2020 - Late treatment study
AVIFAVIR for Treatment of Patients with Moderate COVID-19: Interim Results of a Phase II/III Multicenter Randomized Clinical Trial
Ivashchenko et al., Clin. Infect. Dis., doi:10.1093/cid/ciaa1176 (Peer Reviewed)
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Intermin results for a small RCT with 40 favipiravir and 20 control patients showing faster viral clearance with favipiravir. There is limited data in this report to evaluate the results. The report indicates that 75% of the control group received HCQ/CQ.
risk of no virological cure, 46.4% lower, RR 0.54, p = 0.03, treatment 15 of 40 (37.5%), control 14 of 20 (70.0%), NNT 3.1, mid-recovery day 5.
risk of no virological cure, 62.5% lower, RR 0.37, p = 0.21, treatment 3 of 40 (7.5%), control 4 of 20 (20.0%), NNT 8.0, day 10.
risk of no discharge and WHO-OSC>2, 66.7% higher, RR 1.67, p = 0.51, treatment 10 of 40 (25.0%), control 3 of 20 (15.0%).
risk of hospitalization, 300.0% higher, RR 4.00, p = 0.55, treatment 2 of 40 (5.0%), control 0 of 20 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), 1600/600mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Ivashchenko et al., 8/9/2020, Randomized Controlled Trial, Russia, Europe, peer-reviewed, 21 authors.
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