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0 0.5 1 1.5 2+ Viral clearance 46% Improvement Relative Risk Viral clearance (b) 62% Discharge and WHO-OSC>2 -67% Hospitalization -300% c19favipiravir.com Ivashchenko et al. Favipiravir for COVID-19 RCT LATE Favors favipiravir Favors control
Ivashchenko, 60 patient favipiravir late treatment RCT: 46% improved viral clearance [p=0.03] and 67% lower hospital discharge [p=0.51] https://c19p.org/ivashchenko
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AVIFAVIR for Treatment of Patients with Moderate COVID-19: Interim Results of a Phase II/III Multicenter Randomized Clinical Trial
Ivashchenko et al., Clin. Infect. Dis., doi:10.1093/cid/ciaa1176
9 Aug 2020    Source   PDF   Share   Tweet
Intermin results for a small RCT with 40 favipiravir and 20 control patients showing faster viral clearance with favipiravir. There is limited data in this report to evaluate the results. The report indicates that 75% of the control group received HCQ/CQ.
risk of no viral clearance, 46.4% lower, RR 0.54, p = 0.03, treatment 15 of 40 (37.5%), control 14 of 20 (70.0%), NNT 3.1, mid-recovery day 5.
risk of no viral clearance, 62.5% lower, RR 0.37, p = 0.21, treatment 3 of 40 (7.5%), control 4 of 20 (20.0%), NNT 8.0, day 10.
risk of no discharge and WHO-OSC>2, 66.7% higher, RR 1.67, p = 0.51, treatment 10 of 40 (25.0%), control 3 of 20 (15.0%).
risk of hospitalization, 300.0% higher, RR 4.00, p = 0.55, treatment 2 of 40 (5.0%), control 0 of 20 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), 1600/600mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ivashchenko et al., 8/9/2020, Randomized Controlled Trial, Russia, Europe, peer-reviewed, 21 authors, average treatment delay 6.7 days.
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Late treatment
is less effective
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