Favipiravir COVID-19 studies. Potential risks of the mechanism of action include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity [Hadj Hassine, Waters, Zhirnov].
Recent:Babayigit Bruminhent Tehrani Golan Al-Muhsen Acar Sevinc Usanma Koban.
Favipiravir has been officially adopted
for early treatment in 10 countries (11 including non-government medical organizations).
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Sep 30 |
(Preprint) (meta analysis) | Favipiravir for COVID-19: real-time meta analysis of 51 studies |
| Statistically significant improvements are seen for recovery and viral clearance. 27 studies from 27 independent teams in 16 different countries show statistically significant improvements in isolation (12 for the most serious outcome)... | ||
Sep 10 |
et al., Tropical Medicine and Infectious Disease, doi:10.3390/tropicalmed7090238 | Clinical Course and Outcomes among COVID-19 Patients at the Hospitel in Bangkok: A Retrospective Study |
| 227% higher progression [p=0.005]. Retrospective 514 patients in Thailand, showing higher risk of progression with favipiravir treatment. | ||
Sep 6 |
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac712 | Favipiravir in patients with early mild-to-moderate COVID-19: a randomized controlled trial |
| 2% lower progression [p=1], 4% improved recovery [p=0.79], and 14% faster viral clearance [p<0.0001]. RCT low-risk (1 death in the control arm) patients in the USA, showing no significant differences with favipiravir. A majority of trial outcomes were modified after completion: . 44% of patients had no detectable viral load at baseline in.. | ||
Aug 31 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2022.894126 | The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort |
| 184% higher ventilation [p=0.01], 181% higher ICU admission [p=0.001], and 100% longer hospitalization [p=0.001]. Retrospective 1,472 hospitalized patients in Turkey, showing a higher ICU admission and ventilation with favipiravir. Results may be subject to confounding by indication. | ||
Jun 29 |
et al., Advances in Virology, doi:10.1155/2022/9240941 | Effectiveness of Early Favipiravir Therapy in Hospitalised COVID-19 Patients |
| 96% lower mortality [p<0.0001], 21% lower ICU admission [p=0.45], and 16% shorter hospitalization [p<0.0001]. Retrospective 103 hospitalized patients in Saudi Arabia, showing lower mortality with favipiravir in unadjusted results, and greater efficacy for treatment within 3 days of admission. | ||
Jun 28 |
, S., SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital, doi:10.14744/SEMB.2021.35902 | Favipiravir Experience in COVID-19 Patients at a Tertiary Center Intensive Care Unit |
| 16% lower mortality [p=0.38] and 10% lower ventilation [p=0.75]. Retrospective 100 ICU patients in Turkey, showing improved survival with favipiravir vs. lopinavir/ritonavir. | ||
Jun 15 |
et al., Mediterranean Journal of Infection Microbes and Antimicrobials, doi:10.4274/mjima.galenos.2022.2022.30 | Efficacy of Favipiravir in the Treatment of Moderate COVID-19 Patients: A Randomized, Open-label, Controlled Clinical Trial |
| 34% lower hospitalization [p=0.24]. RCT 78 patients in Iran, showing improved recovery with favipiravir treatment. | ||
Jun 15 |
et al., Antibiotics, doi:10.3390/antibiotics11060805 | Real-World Effectiveness and Optimal Dosage of Favipiravir for Treatment of COVID-19: Results from a Multicenter Observational Study in Thailand |
| Retrospective 63 hospitalized patients in Thailand treated with favipiravir showing a lower favipiravir loading dose negatively associated with clinical improvement. | ||
Jun 14 |
et al., SSRN Electronic Journal, doi:10.2139/ssrn.4135325 | Favipiravir in Early Symptomatic COVID-19, A Randomised Placebo-Controlled Trial |
| 1% higher need for oxygen therapy [p=1] and 56% higher hospitalization [p=0.38]. RCT with 99 favipiravir and 100 placebo patients in Australia, all except one being outpatients, showing no significant differences with treatment. | ||
Jun 8 |
et al., medRxiv, doi:10.1101/2022.06.06.22275902 | Early Treatment of Favipiravir in COVID-19 Patients Without Pneumonia: A Multicentre, Open-Labelled, Randomized Control Study |
| 64% faster improvement [p=0.0005], 43% lower progression [p=0.25], and 4% worse viral clearance [p=0.87]. RCT 93 patients in Thailand showing significantly faster clinical improvement with favipiravir treatment. 1800mg favipiravir bid day 1, 800mg bid 5-14 days until PCR-. | ||
Jun 7 |
et al., Bratislava Medical Journal, doi:10.4149/BLL_2022_082 | The factors affecting the prolonged PCR positivity in COVID-19 patients |
| 86% improved viral clearance [p=0.03]. Retrospective 126 patients in Turkey, showing lower risk of PCR+ at day 14 with favipiravir treatment. | ||
May 23 |
et al., International Journal of Applied Sciences: Current and Future Research Trends, 13:1 | Efficacy of Favipiravir in the Treatment of Mild to Moderate COVID-19 Patients in Erbil: A Controlled Clinical Trial |
| 97% lower mortality [p<0.0001], 60% lower hospitalization [p=0.001], and 97% improved recovery [p<0.0001]. Prospective study with 125 favipiravir patients and 125 patients declining favipiravir treatment, showing lower mortality and improved recovery with treatment. All patients received vitamin C, D, and zinc. Favipiravir 3200mg day 1, follow.. | ||
May 17 |
et al., Expert Review of Clinical Pharmacology, doi:10.1080/17512433.2022.2078701 (meta analysis) | Favipiravir-based treatment for outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials |
| Systematic review and meta analysis of favipiravir RCTs, showing improved viral clearance and recovery, but no significant difference for mortality, ICU admission, or ventilation. | ||
May 13 |
et al., Clinical Infection in Practice, doi:10.1016/j.clinpr.2022.100145 | Safety and Efficacy of Favipiravir for the management of COVID-19 Patients: A Randomized Control Trial |
| 89% better improvement [p=0.005] and 92% improved viral clearance [p=0.0008]. RCT hospitalized patients in Bangladesh, showing faster recovery and viral clearance with favipiravir treatment. | ||
May 3 |
et al., International Journal of General Medicine, doi:10.2147/IJGM.S349241 | Evaluation of the Safety and Efficacy of Favipiravir in Adult Indian Patients with Mild-to-Moderate COVID-19 in a Real-World Setting |
| Prospective single-arm study of 1,083 patients receiving favipiravir in India, showing one death and no new safety issues. | ||
Apr 22 |
et al., SSRN, doi:10.2139/ssrn.3889346 (meta analysis) | The efficacy and adverse effects of favipiravir on COVID-19 patients: a systematic review and meta-analysis of published clinical trials and observational studies |
| Systematic review and meta analysis of 17 favipiravir trials, showing improved viral clearance and recovery. | ||
Apr 18 |
et al., Viruses, doi:10.3390/v14040841 (Review) | Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity |
| Review of lethal mutagenesis for RNA viruses, as used by molnupiravir, favipiravir, and ribavirin. Authors note the potential for permanently modifying the genomes of patients while causing teratogenicity or embryotoxicity, and the potent.. | ||
Apr 8 |
et al., Antibiotics, doi:10.3390/antibiotics11040498 | Antiviral Used among Non-Severe COVID-19 Cases in Relation to Time till Viral Clearance: A Retrospective Cohort Study |
| 3% slower viral clearance [p=0.09]. Retrospective hospitalized patients in the United Arab Emirates, showing no significant difference in viral clearance with different combinations of HCQ, AZ, favipiravir, and lopinavir/ritonavir. | ||
Mar 24 |
et al., Viruses, doi:10.3390/v14040670 | Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir |
| 7% shorter hospitalization [p=0.84] and 55% faster viral clearance [p=0.04]. Retrospective 17 COVID+ patients treated with favipiravir and 17 matched controls in Japan, showing faster viral clearance with treatment. Favipiravir 3600mg day one, 1600mg per day for up to 14 days. | ||
Mar 23 |
et al., Scientific Reports, doi:10.1038/s41598-022-08794-w | Randomized controlled trial of favipiravir, hydroxychloroquine, and standard care in patients with mild/moderate COVID-19 disease |
| 76% lower ICU admission [p=0.2], 42% worse recovery [p=0.51], and 43% improved viral clearance [p=0.21]. RCT with 54 favipiravir, 51 HCQ, and 52 SOC hospitalized patients in Bahrain, showing no significant differences. Viral clearance improved with both treatments, but did not reach statistical significance with the small sample size. | ||
Mar 21 |
et al., Infectious Diseases and Therapy, doi:10.1007/s40121-022-00617-9 | Effectiveness of Favipiravir on Nonsevere, Early-Stage COVID-19 in Japan: A Large Observational Study Using the COVID-19 Registry Japan |
| 13% lower mortality [p=0.59], 2% higher ventilation [p=0.93], and 18% lower progression [p=0.1]. Retrospective database analysis of 7,654 hospitalized patients in Japan, showing no significant differences with favipiravir treatment. NCGM-G-003494-0. | ||
Mar 17 |
et al., Acta Medica, doi:10.32552/2022.ActaMedica.719 | Comparison of Favipiravir to Hydroxychloroquine Plus Azithromycin in the Treatment of Patients with Non-critical COVID-19: A Single-center, Retrospective, Propensity Score-matched Study |
| 67% lower mortality [p=1], 200% higher ICU admission [p=1], and 11% longer hospitalization [p=0.9]. PSM retrospective 260 late stage hospitalized COVID-19 pneumonia patients in Turkey, showing no significant difference between favipiravir and HCQ. | ||
Mar 24 |
et al., Journal of Medical Virology, doi:10.1002/jmv.27724 | Efficacy and safety of favipiravir plus interferon-beta versus lopinavir/ritonavir plus interferon-beta in moderately ill patients with COVID-19: A randomized clinical trial |
| 68% lower mortality [p=0.15], 35% lower ICU admission [p=0.51], 25% shorter hospitalization [p=0.14], and 18% improved viral clearance [p=0.24]. RCT comparing favipiravir and lopinavir/ritonavir, showing no significant differences. All patients received interferon-beta. Favipiravir 1600mg bid for the first day and 600mg bid for the following 4 days. | ||
Mar 7 |
et al., Pathophysiology, doi:10.3390/pathophysiology29010009 | Evaluation of Antibacterial and Antiviral Drug Effectiveness in COVID-19 Therapy: A Data-Driven Retrospective Approach |
| 85% lower mortality [p=0.05]. Retrospective hospitalized patients in Indonesia, showing lower mortality and shorter hospitalization with favipiravir. | ||
Mar 4 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2022.826247 | Favipiravir Effectiveness and Safety in Hospitalized Moderate-Severe COVID-19 Patients: Observational Prospective Multicenter Investigation in Saudi Arabia |
| 263% higher mortality [p=0.04], 41% lower need for oxygen therapy [p<0.0001], and 40% longer hospitalization [p=0.03]. Prospective observational study of 598 hospitalized patients in Saudi Arabia, showing higher risk of mortality and longer hospitalization time with favipiravir. | ||
Mar 3 |
et al., Respiratory Medicine and Research, doi:10.1016/j.resmer.2022.100900 | Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study |
| 38% lower mortality [p=0.51]. Retrospective 46 idiopathic pulmonary fibrosis patients with COVID-19 in Turkey, showing lower mortality with favipiravir in unadjusted results, without statistical significance. | ||
Mar 1 |
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.109 | Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center, randomized, open-labelled, phase III clinical trial |
| 40% worse improvement [p=0.57]. Preliminary report for an RCT in Nepal with 38 favipiravir patients and 32 control patients, showing no significant differences. There were no serious side effects. | ||
Feb 28 |
et al., Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100068 | Factors Associated with Death and ICU Referral among COVID-19 Patients Hospitalized in the Secondary Referral Academic Hospital in East Jakarta, Indonesia |
| 48% lower mortality [p=0.21]. Retrospective 477 hospitalized patients in Indonesia, showing lower mortality with favipiravir in unadjusted results, not reaching statistical significance. | ||
Feb 15 |
et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.01.013 | Overview of Clinical Outcome and Therapeutic Effectiveness of Favipiravir in Patients with COVID-19 Admitted to Intensive Care Unit, Riyadh, Saudi Arabia |
| 7% lower mortality [p=0.49], 9% higher ARDS [p=0.63], 34% longer ICU admission [p=0.001], and 37% longer hospitalization [p=0.001]. Retrospective 269 favipiravir ICU patients in Saudi Arabia and 269 matched controls receiving different treatments, showing no significant difference. | ||
Feb 15 |
et al., medRxiv, doi:10.1101/2022.02.11.22270775 (Preprint) | Favipiravir, lopinavir-ritonavir or combination therapy (FLARE): a randomised, double blind, 2x2 factorial placebo-controlled trial of early antiviral therapy in COVID-19 |
| 28% improved viral clearance [p=0.03]. 240 patient RCT comparing favipiravir, favipiravir + LPV/r, LPV/r, and placebo, showing improved viral clearance with favipiravir. Efficacy was lower in the combined favipiravir + LPV/r arm, where plasma levels of favipiravir were lower. .. | ||
Feb 1 |
et al., The Brazilian Journal of Infectious Diseases, doi:10.1016/j.bjid.2022.102328 | The effect of favipiravir versus hydroxychloroquine on clinical and laboratory findings in COVID-19 in healthcare workers |
| 79% lower hospitalization [p=0.001], 11% slower recovery [p=0.51], and 22% faster viral clearance [p=0.001]. Retrospective 237 low-risk healthcare workers in Turkey, 123 treated with favipiravir and 114 treated with HCQ, showing lower hospitalization and faster viral clearance with favipiravir, and similar improvement. This study is subject to s.. | ||
Jan 28 |
et al., Environmental and Molecular Mutagenesis, doi:10.1002/em.22471 (Review) | Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir |
| Review of antiviral nucleoside analog drugs that induce lethal mutagenesis, including molnupiravir and favipiravir, and the potential mutagenic risks to human DNA and human mitochondrial DNA. Author recommends monitoring for mutagenicity,.. | ||
Jan 12 |
et al., bioRxiv, doi:10.1101/2022.01.11.475889 (Preprint) (In Vitro) | Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2 |
| In Vitro and In Silico study showing that the combination of favipiravir and umifenovir or camostat mesylate has greater antiviral efficacy than single drug treatment. | ||
Jan 11 |
et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2021.12.026 | Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicenter, placebo-controlled trial clinical trial |
| 619% higher ICU admission [p=0.11], 219% higher hospitalization [p=0.16], 12% slower recovery [p=0.51], and 15% slower viral clearance [p=0.51]. RCT with 112 favipiravir and 119 control patients showing no significant differences in outcomes. Viral clearance and clinical recovery for patients treated within 48 hours was better than those treated later. NCT04464408. | ||
Dec 7 2021 |
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab56310 | US201 Study: A Phase 2, Randomized Proof-of-Concept Trial of Favipiravir for the Treatment of COVID-19 |
| 20% longer hospitalization, 58% improved recovery [p=0.08], and 47% faster viral clearance [p=0.04]. Small very late treatment RCT in the USA, with 25 favipiravir and 25 control patients, showing faster viral clearance with treatment. The benefit was only seen in patients <8 days from symptom onset. There were no significant differences .. | ||
Nov 30 2021 |
et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.08.011 (date from earlier preprint) | Favipiravir for the Treatment of Coronavirus Disease 2019 Pneumonia; a Propensity Score-matched Cohort Study |
| 33% lower mortality [p=0.5], 2% worse recovery [p=0.73], and 44% improved viral clearance [p<0.0001]. PSM retrospective with 1,493 patients, showing significantly improved viral clearance with favipiravir. There were no significant differences in clinical improvement or mortality. Mortality was lower (2.1% vs 3.1%), without statistical si.. | ||
Nov 24 2021 |
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac312 (date from earlier preprint) | Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial |
| 89% lower hospitalization [p=0.06], 30% lower progression [p=0.56], 19% worse recovery [p=0.43], and 32% worse viral clearance [p=0.24]. Small RCT 116 mITT patients in the USA, 59 treated with favipiravir, showing no significant differences with treatment. | ||
Nov 19 2021 |
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciab962 | Efficacy of Early Treatment with Favipiravir on Disease Progression among High Risk COVID-19 Patients: A Randomized, Open-Label Clinical Trial |
| 1154% higher mortality [p=0.08], 20% higher ventilation [p=0.76], and 9% higher ICU admission [p=0.84]. RCT 500 hospitalized patients in Malaysia, showing no significant differences with favipiravir treatment. | ||
Nov 9 2021 |
et al., medRxiv, doi:10.1101/2021.11.08.21265884 (Preprint) | Favipiravir In Adults with Moderate to Severe COVID-19: A Phase 3 Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial |
| 29% higher mortality [p=0.54], 33% higher ventilation [p=0.54], 2% higher ICU admission [p=0.54], and 1% slower recovery [p=0.94]. Late stage RCT with 353 hospitalized patients, showing no significant differences with favipiravir treatment overall, however a trend towards benefit was seen within patients treated relatively early, including a statistically significant.. | ||
Nov 1 2021 |
et al., Kesmas: National Public Health Journal, doi:10.21109/kesmas.v16i4.5433 | The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients in Bali, Indonesia |
| 54% improved recovery [p=0.03]. Retrospective 192 hospitalized patients in Indonesia, 96 patients treated with favipiravir, showing improved recovery with treatment. Only the abstract is currently available. | ||
Oct 5 2021 |
et al., SSRN Electronic Journal, doi:10.2139/ssrn.3936499 | Various Combinations of Favipiravir, Lopinavir-Ritonavir, Darunavir-Ritonavir, High-Dose Oseltamivir, and Hydroxychloroquine for the Treatment of COVID-19: A Randomized Controlled Trial (FIGHT-COVID-19 Study) |
| 23% lower mortality [p=0.66], 60% lower progression [p=0.009], and 9% faster viral clearance [p=0.43]. RCT 200 moderate/severe patients in Thailand, showing significantly lower progression with favipiravir vs. oseltamivir. NCT04303299. | ||
Sep 30 2021 |
et al., Iranian Journal of Pharmaceutical Research, doi:10.22037/ijpr.2021.115510.15401 | Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage Form |
| 41% lower ICU admission [p=0.36], 6% improved recovery [p=0.76], and 25% shorter hospitalization [p=0.03]. Small 62 patient late stage RCT in Iran comparing favipiravir and lopinavir/ritonavir, showing significant improvement in fever, cough, and dyspnea with favipiravir on day 5. There was no significant difference in mortality, ICU admission.. | ||
Sep 14 2021 |
et al., International Journal of General Medicine, 2021:14 | Effectiveness and Safety of Favipiravir Compared to Hydroxychloroquine for Management of Covid-19: A Retrospective Study |
| 57% lower mortality [p=0.05]. Retrospective hospitalized patients in Saudi Arabia, showing lower mortality with favipiravir compared to HCQ, not quite reaching statistical significance. Authors do not indicate the factors behind which therapy was chosen. May be subjec.. | ||
Sep 9 2021 |
et al., Southeast Asian Journal of Tropical Medicine and Public Health, 52:4 | Assessment of outcomes following implementation of antiviral treatment guidelines for COVID-19 during the first wave in Thailand |
| 68% lower progression [p=0.003]. Retrospective 744 hospitalized patients in Thailand, showing lower risk of a poor outcome for favipiravir treatment within 4 days of symptom onset. Early treatment with CQ/HCQ and lopinavir/ritonavir or darunavir/ritonavir also showed low.. | ||
Sep 2 2021 |
et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.683296 | Favipiravir Versus Arbidol for Clinical Recovery Rate in Moderate and Severe Adult COVID-19 Patients: A Prospective, Multicenter, Open-Label, Randomized Controlled Clinical Trial |
| 74% lower progression [p=0.37], 20% lower need for oxygen therapy [p=0.42], and 20% improved recovery [p=0.15]. Very late stage (9 days from symptom onset) RCT with 116 favipiravir patients and 120 arbidol patients in China, showing no significant difference in clinical recovery (relief of fever and cough, respiratory frequency ≤24 times/min, and o.. | ||
Aug 31 2021 |
et al., | Clinical efficacy of the antiviral drug favipiravir in the complex treatment of patients with COVID-19 coronavirus infection |
| 88% better improvement [p<0.0001] and 50% improved viral clearance [p=0.18]. Retrospective 40 favipiravir patients in Kazakhstan and 40 controls, showing faster recovery and viral clearance with treatment. | ||
Aug 28 2021 |
et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.030 | COVID-19 related treatment and outcomes among COVID-19 ICU patients: A retrospective cohort study |
| 79% higher mortality [p=0.5]. Retrospective 118 ICU patients in Saudi Arabia showing no significant differences in unadjusted results with zinc, vitamin D, and favipiravir treatment. | ||
Aug 27 2021 |
et al., Infectious Diseases and Therapy, doi:10.1007/s40121-021-00517-4 | Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial |
| 37% faster recovery [p=0.01]. RCT 156 patients in Japan, 107 treated with favipiravir, showing significant improvement in a composite outcome defined as the time to improvement in temperature, SpO2, CT findings, and recovery to PCR-. | ||
Aug 24 2021 |
et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.022 | Favipiravir versus Standard of Care in Patients with Severe COVID-19 Infections: A Retrospective Comparative Study |
| 42% higher mortality [p=0.1], 90% higher ICU admission [p=0.02], and 11% slower recovery [p=0.17]. Retrospective 226 COVID-19 pneumonia patients, 110 treated with favipiravir, showing higher mortality (p=0.1) and ICU admission (p=0.02) with treatment in multivariate analysis. | ||
May 19 2021 |
et al., Current Medical Research and Opinion, doi:10.1080/03007995.2021.1920900 | Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis |
| 56% higher mortality [p=0.26], 90% lower ventilation [p<0.0001], and 49% higher hospital discharge [p<0.0001]. Retrospective 234 favipiravir and 223 control patients in Saudi Arabia, showing shorter time to discharge and lower progression to ventilation, but no significant difference in mortality. | ||
May 5 2021 |
et al., Journal of microbiology, epidemiology and immunobiology, doi:10.36233/0372-9311-114 (Review) | Favipiravir: the hidden threat of mutagenic action |
| Review of the mutagenic effect of favipiravir and associated concerns. | ||
Apr 29 2021 |
et al., Journal of Medical Virology, doi:10.1002/jmv.27053 | Decreased In-Hospital Mortality Associated with Aspirin Administration in Hospitalized Patients Due to Severe COVID-19 |
| 26% lower mortality [p=0.28]. Retrospective 991 hospitalized patients in Iran focusing on aspirin use but also showing results for HCQ, remdesivir, and favipiravir. | ||
Apr 21 2021 |
et al., International Immunopharmacology, doi:10.1016/j.intimp.2021.107702 | Favipiravir in the treatment of patients with SARS-CoV-2 RNA recurrent positive after discharge: a multicenter, open-label, randomized trial |
| 59% improved viral clearance [p=0.06]. RCT with 55 patients (36 favipiravir, 19 control) who were PCR+ after recovery, showing improved viral clearance with treatment. | ||
Apr 19 2021 |
, Fujita Health University (Preprint) | Favipiravir Observational Study Interim Report 3 |
| Retrospective analysis of favipiravir use in 10,986 hospitalized patients, including analysis of changes in clinical status and side effects. Common adverse events were uric acid level increase and liver function enzyme increase. Authors .. | ||
Apr 17 2021 |
et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2021.04.013 | Early favipiravir treatment was associated with early defervescence in non-severe COVID-19 patients |
| Retrospective 41 favipiravir patients finding that early treatment was more successful. | ||
Mar 11 2021 |
et al., International Immunopharmacology, doi:10.1016/j.intimp.2021.107522 | Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia |
| 19% higher mortality [p=0.54], 53% higher ventilation [p=0.15], and 19% higher ICU admission [p=0.56]. RCT late stage patients (median SpO2 89), 193 treated with favipiravir, 187 with lopinavir/ritonavir, showing no significant differences in mortality, intubation, or ICU admission. | ||
Mar 8 2021 |
et al., medRxiv, doi:10.1101/2021.03.05.21251351 (Preprint) | A single-center retrospective cohort study of Covid-19 medications: Remdesivir, Favipiravir, Methylprednisolone, Dexamethasone, and Interferon β1a and their combinations |
| Retrospective 324 hospitalized patients in Iran reporting on the use Remdesivir, Favipiravir, Methylprednisolone, Dexamethasone, and Interferon β1a and their combinations. There is no control group in this study. | ||
Feb 4 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-175340/v1 (Preprint) | Benefits of Treatment With Favipiravir in Hospitalized Patients for COVID-19: a Retrospective Observational Case-control Study |
| Retrospective 144 COVID-19 patients in Turkey, one group receiving FPV after a mean of 4.7 days, a second group after a mean of 8.6 days, and all groups receiving HCQ. No improvement in clinical outcomes was seen with the addition of FPV,.. | ||
Jan 25 2021 |
et al., Archives of Virology, doi:10.1007/s00705-021-04956-9 | Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study |
| This study was retracted. | ||
Jan 14 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-142868/v1 (Preprint) | Early Onset Favipiravir Saves Lives |
| Retrospective 180 hospitalized patients showing lower mortality when Favipiravir is given earlier. 17% of patients given Favipiravir within 3 days died, compared to 38% when given after 3 days. | ||
Nov 17 2020 |
et al., Antimicrobial Agents and Chemotherapy, doi:10.1128/AAC.01897-20 | A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19 |
| Small RCT comparing late and very late (7 and 14 days from fever onset) favipiravir. Viral clearance was non-statistically significantly improved with relatively early treatment. There was a reduction in time to defervescence, and a signi.. | ||
Nov 16 2020 |
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.11.142 | Efficacy and Safety of Favipiravir, an Oral RNA-Dependent RNA Polymerase Inhibitor, in Mild-to-Moderate COVID-19: A Randomized, Comparative, Open-Label, Multicenter, Phase 3 Clinical Trial |
| 40% faster recovery [p=0.03] and 29% faster viral clearance [p=0.13]. RCT with 75 favipiravir patients and 75 control patients showing reduced time to clinical cure and reduced time of viral shedding. | ||
Nov 9 2020 |
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.11.008 | Randomized Controlled Open Label Trial on the Use of Favipiravir Combined with Inhaled Interferon beta-1b in Hospitalized Patients with Moderate to Severe COVID-19 Pneumonia |
| 15% lower mortality [p=1], 2% higher ICU admission [p=1], and 10% worse recovery [p=0.82]. Small 89 patient RCT comparing favipiravir and inhaled interferon with HCQ for moderate to severe COVID-19 pneumonia, not finding significant differences. There was no control group. | ||
Nov 5 2020 |
et al., NCT04542694 (Preprint) | Study of Favipiravir Compared to Standard of Care in Hospitalized Patients With COVID-19 |
| 14% improved recovery [p=0.06], 70% higher hospital discharge [p=0.0001], 33% lower pneumonia [p=0.007], and 90% improved viral clearance [p<0.0001]. RCT 200 patients showing improvements in clinical recovery and viral clearance with favipiravir. There is no paper available but results are posted in clinicaltrials.gov. | ||
Oct 26 2020 |
et al., SSRN, doi:10.2139/ssrn.3696907 (Preprint) | Phase 3 Trial of Coronavir (Favipiravir) in Patients with Mild to Moderate COVID-19 |
| 39% faster recovery [p=0.007] and 22% improved viral clearance [p=0.16]. RCT 168 patients, 112 receiving favipiravir and 56 SOC, showing shorter time to clinical improvement and faster viral clearance with favipiravir. | ||
Oct 25 2020 |
et al., European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2020.105631 | Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial |
| 422% higher ICU admission [p=0.21] and 422% worse viral clearance [p=0.21]. Small late stage RCT with 10 favipiravir, 10 baloxavir marboxil, and 10 control patients in China, showing no significant differences. ChiCTR 2000029544. | ||
Sep 30 2020 |
et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2020.110825 | Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size |
| Small study with 14 combined favipiravir/tocilizumab, 7 favipiravir, and 5 tocilizumab patients suggesting that tocilizumab combined with or without favipiravir can improve pulmonary inflammation and inhibit progression. | ||
Aug 9 2020 |
et al., Clin. Infect. Dis., doi:10.1093/cid/ciaa1176 | AVIFAVIR for Treatment of Patients with Moderate COVID-19: Interim Results of a Phase II/III Multicenter Randomized Clinical Trial |
| 46% improved viral clearance [p=0.03] and 67% lower hospital discharge [p=0.51]. Intermin results for a small RCT with 40 favipiravir and 20 control patients showing faster viral clearance with favipiravir. There is limited data in this report to evaluate the results. The report indicates that 75% of the control group.. | ||
Jun 19 2020 |
et al., bioRxiv, doi:10.1101/2020.06.19.159053 | Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity |
| Animal study with Syrian hamsters, showing antiviral activity with favipiravir. | ||
Mar 18 2020 |
et al., Engineering, doi:10.1016/j.eng.2020.03.007 | Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study |
| 69% lower pneumonia [p=0.04] and 71% improved viral clearance [p=0.03]. Comparison of 35 FPV patients and 35 LPV/RTV patients, showing significant improvements in chest CT and faster viral clearance with FPV. | ||
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