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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -196% Improvement Relative Risk ICU admission 76% Recovery -42% Viral clearance 43% c19favipiravir.com AlQahtani et al. NCT04387760 Favipiravir RCT LATE Favors favipiravir Favors control
AlQahtani, 106 patient favipiravir late treatment RCT: 76% lower ICU admission [p=0.2], 42% worse recovery [p=0.51], and 43% improved viral clearance [p=0.21] https://c19p.org/alqahtani2a
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Randomized controlled trial of favipiravir, hydroxychloroquine, and standard care in patients with mild/moderate COVID-19 disease
AlQahtani et al., Scientific Reports, doi:10.1038/s41598-022-08794-w
23 Mar 2022    Source   PDF   Share   Tweet
RCT with 54 favipiravir, 51 HCQ, and 52 SOC hospitalized patients in Bahrain, showing no significant differences. Viral clearance improved with both treatments, but did not reach statistical significance with the small sample size. NCT04387760.
risk of death, 196.3% higher, RR 2.96, p = 1.00, treatment 1 of 54 (1.9%), control 0 of 52 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 75.9% lower, RR 0.24, p = 0.20, treatment 1 of 54 (1.9%), control 4 of 52 (7.7%), NNT 17.
risk of no recovery, 41.9% higher, RR 1.42, p = 0.51, treatment 8 of 53 (15.1%), control 5 of 47 (10.6%).
risk of no viral clearance, 42.9% lower, RR 0.57, p = 0.21, treatment 8 of 40 (20.0%), control 14 of 40 (35.0%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
AlQahtani et al., 3/23/2022, Randomized Controlled Trial, Bahrain, Middle East, peer-reviewed, 13 authors, study period August 2020 - March 2021, trial NCT04387760.
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Late treatment
is less effective
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