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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 30% Improvement Relative Risk ICU admission 41% <50% improvement in ch.. 6% Hospitalization time 25% c19favipiravir.com/tabarsi.html Favors favipiravir Favors lopinavir/ri..
30 September 2021 - Late treatment study
Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage Form
Tabarsi et al., Iranian Journal of Pharmaceutical Research, doi:10.22037/ijpr.2021.115510.15401 (Peer Reviewed)
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Small 62 patient late stage RCT in Iran comparing favipiravir and lopinavir/ritonavir, showing significant improvement in fever, cough, and dyspnea with favipiravir on day 5. There was no significant difference in mortality, ICU admission, or chest CT improvement. IRCT20151227025726N14.
risk of death, 29.7% lower, RR 0.70, p = 0.70, treatment 3 of 32 (9.4%), control 4 of 30 (13.3%), NNT 25.
risk of ICU admission, 41.4% lower, RR 0.59, p = 0.36, treatment 5 of 32 (15.6%), control 8 of 30 (26.7%), NNT 9.1.
risk of <50% improvement in chest CT, 6.2% lower, RR 0.94, p = 0.76, treatment 24 of 32 (75.0%), control 24 of 30 (80.0%), NNT 20.
hospitalization time, 25.0% lower, relative time 0.75, p = 0.03, treatment 32, control 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Tabarsi et al., 9/30/2021, Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 27 authors, study period 4 April, 2020 - 7 May, 2020, average treatment delay 7.0 days, this trial compares with another treatment - results may be better when compared to placebo.
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