Tabarsi: Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage Form

Tabarsi, 62 patient favipiravir late treatment RCT: 41% lower ICU admission [p=0.36], 6% improved recovery [p=0.76], and 25% shorter hospitalization [p=0.03] https://c19p.org/tabarsi

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Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage Form

Tabarsi et al., Iranian Journal of Pharmaceutical Research, doi:10.22037/ijpr.2021.115510.15401

30 Sep 2021 Source PDF Share Tweet

Small 62 patient late stage RCT in Iran comparing favipiravir and lopinavir/ritonavir, showing significant improvement in fever, cough, and dyspnea with favipiravir on day 5. There was no significant difference in mortality, ICU admission, or chest CT improvement. IRCT20151227025726N14.

risk of death, 29.7% lower, RR 0.70, p = 0.70, treatment 3 of 32 (9.4%), control 4 of 30 (13.3%), NNT 25.

risk of ICU admission, 41.4% lower, RR 0.59, p = 0.36, treatment 5 of 32 (15.6%), control 8 of 30 (26.7%), NNT 9.1.

risk of <50% improvement in chest CT, 6.2% lower, RR 0.94, p = 0.76, treatment 24 of 32 (75.0%), control 24 of 30 (80.0%), NNT 20.

hospitalization time, 25.0% lower, relative time 0.75, p = 0.03, treatment 32, control 30.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Tabarsi et al., 9/30/2021, Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 27 authors, study period 4 April, 2020 - 7 May, 2020, average treatment delay 7.0 days, this trial compares with another treatment - results may be better when compared to placebo.

All Studies Meta Analysis

This Paper Favipiravir All

Late treatment
is less effective

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