3/11 Late treatment study
et al., International Immunopharmacology, doi:10.1016/j.intimp.2021.107522 (Peer Reviewed)
Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia
Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia
RCT late stage patients (median SpO2 89), 193 treated with favipiravir, 187 with lopinavir/ritonavir, showing no significant differences in mortality, intubation, or ICU admission.
Solaymani-Dodaran et al., 3/11/2021, Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 44 authors, this trial compares with another treatment - results may be better when compared to placebo.
risk of death, 19.2% higher, RR 1.19, p = 0.54, treatment 26 of 190 (13.7%), control 21 of 183 (11.5%).
risk of mechanical ventilation, 53.0% higher, RR 1.53, p = 0.15, treatment 27 of 190 (14.2%), control 17 of 183 (9.3%).
risk of ICU admission, 19.4% higher, RR 1.19, p = 0.56, treatment 31 of 190 (16.3%), control 25 of 183 (13.7%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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