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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Time to improvement 37% Improvement Relative Risk Time to improvement (b) 59% c19favipiravir.com/shinkai.html Favors favipiravir Favors control
27 August 2021 - Late treatment study
Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial
Shinkai et al., Infectious Diseases and Therapy, doi:10.1007/s40121-021-00517-4 (Peer Reviewed)
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RCT 156 patients in Japan, 107 treated with favipiravir, showing significant improvement in a composite outcome defined as the time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
time to improvement, 37.1% lower, RR 0.63, p = 0.01, treatment 107, control 49, adjusted per study, Cox proportional hazards, composite time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
time to improvement, 58.5% lower, RR 0.41, p = 0.01, treatment 47, control 13, adjusted per study, <5 days from onset of fever, Cox proportional hazards, composite time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Shinkai et al., 8/27/2021, Single Blind Randomized Controlled Trial, Japan, Asia, peer-reviewed, 39 authors.
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