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Home   COVID-19 treatment studies for Favipiravir  COVID-19 treatment studies for Favipiravir  C19 studies: Favipiravir  Favipiravir   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 6% Improvement Relative Risk Mechanical ventilation -150% ICU admission -51% Hazard ratio for time .. 39% Virological cure 22% c19favipiravir.com/ruzhentsova.html Favors favipiravir Favors control
26 October 2020 - Early treatment study
Phase 3 Trial of Coronavir (Favipiravir) in Patients with Mild to Moderate COVID-19
Ruzhentsova et al., SSRN, doi:10.2139/ssrn.3696907 (Preprint)
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RCT 168 patients, 112 receiving favipiravir and 56 SOC, showing shorter time to clinical improvement and faster viral clearance with favipiravir.
risk of hospitalization, 6.0% lower, RR 0.94, p = 0.49, treatment 3 of 112 (2.7%), control 2 of 56 (3.6%), NNT 112, adjusted per study.
risk of mechanical ventilation, 150.0% higher, RR 2.50, p = 1.00, treatment 1 of 112 (0.9%), control 0 of 56 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 51.0% higher, RR 1.51, p = 0.63, treatment 3 of 112 (2.7%), control 1 of 56 (1.8%), adjusted per study.
hazard ratio for time to clinical improvement, 38.7% lower, RR 0.61, p = 0.007, treatment 112, control 56.
risk of no virological cure, 21.9% lower, RR 0.78, p = 0.16, treatment 112, control 56, day 5 mid-recovery.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Ruzhentsova et al., 10/26/2020, Randomized Controlled Trial, Russia, Europe, preprint, 31 authors, average treatment delay 3.55 days.
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