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0 0.5 1 1.5 2+ Hospitalization 6% Improvement Relative Risk Ventilation -150% ICU admission -51% Hazard ratio for time to cl.. 39% Viral clearance 22% c19favipiravir.com Ruzhentsova et al. Favipiravir for COVID-19 RCT EARLY Favors favipiravir Favors control
Ruzhentsova, 168 patient favipiravir early treatment RCT: 39% faster recovery [p=0.007] and 22% improved viral clearance [p=0.16] https://c19p.org/ruzhentsova
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Phase 3 Trial of Coronavir (Favipiravir) in Patients with Mild to Moderate COVID-19
Ruzhentsova et al., SSRN, doi:10.2139/ssrn.3696907 (Preprint)
26 Oct 2020    Source   PDF   Share   Tweet
RCT 168 patients, 112 receiving favipiravir and 56 SOC, showing shorter time to clinical improvement and faster viral clearance with favipiravir.
risk of hospitalization, 6.0% lower, RR 0.94, p = 0.49, treatment 3 of 112 (2.7%), control 2 of 56 (3.6%), adjusted per study.
risk of mechanical ventilation, 150.0% higher, RR 2.50, p = 1.00, treatment 1 of 112 (0.9%), control 0 of 56 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 51.0% higher, RR 1.51, p = 0.63, treatment 3 of 112 (2.7%), control 1 of 56 (1.8%), adjusted per study.
hazard ratio for time to clinical improvement, 38.7% lower, HR 0.61, p = 0.007, treatment 112, control 56.
risk of no viral clearance, 21.9% lower, RR 0.78, p = 0.16, treatment 112, control 56, day 5 mid-recovery.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ruzhentsova et al., 10/26/2020, Randomized Controlled Trial, Russia, Europe, preprint, 31 authors, average treatment delay 3.55 days.
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