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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Clinical status improv.. 14% Improvement Relative Risk Time to clinical improve.. 33% Fever reduction by day 3 45% Time to resolution of fever 20% Discharge at day 10 70% Full recovery at day 10 27% Improvement in lung CT 33% Viral clearance 90% c19favipiravir.com Pushkar et al. Favipiravir for COVID-19 RCT LATE Favors favipiravir Favors control
Pushkar, 200 patient favipiravir late treatment RCT: 14% improved recovery [p=0.06], 70% higher hospital discharge [p=0.0001], 33% lower pneumonia [p=0.007], and 90% improved viral clearance [p<0.0001] https://c19p.org/pushkar
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Study of Favipiravir Compared to Standard of Care in Hospitalized Patients With COVID-19
Pushkar et al., NCT04542694 (Preprint)
5 Nov 2020    Source   PDF   Share   Tweet
RCT 200 patients showing improvements in clinical recovery and viral clearance with favipiravir. There is no paper available but results are posted in clinicaltrials.gov.
risk of no clinical status improvement of 2+ WHO-OSCI at ~10 days, 14.1% lower, RR 0.86, p = 0.06, treatment 73 of 100 (73.0%), control 85 of 100 (85.0%), NNT 8.3.
relative time to clinical improvement, 33.3% lower, relative time 0.67, p < 0.001, treatment 100, control 100.
risk of no fever reduction by day 3, 45.2% lower, RR 0.55, p < 0.001, treatment 40 of 100 (40.0%), control 73 of 100 (73.0%), NNT 3.0.
relative time to resolution of fever, 20.0% lower, relative time 0.80, p = 0.05, treatment 100, control 100.
risk of no discharge at day 10, 69.7% lower, RR 0.30, p < 0.001, treatment 10 of 100 (10.0%), control 33 of 100 (33.0%), NNT 4.3.
risk of no full recovery at day 10, 26.7% lower, RR 0.73, p < 0.001, treatment 66 of 100 (66.0%), control 90 of 100 (90.0%), NNT 4.2.
risk of no improvement in lung CT, 33.3% lower, RR 0.67, p = 0.007, treatment 40 of 100 (40.0%), control 60 of 100 (60.0%), NNT 5.0.
risk of no viral clearance, 90.5% lower, RR 0.10, p < 0.001, treatment 2 of 100 (2.0%), control 21 of 100 (21.0%), NNT 5.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pushkar et al., 11/5/2020, Randomized Controlled Trial, Russia, Europe, preprint, mean age 50.0, 1 author.
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Late treatment
is less effective
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