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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ ICU admission -422% Improvement Relative Risk Viral clearance, day 14 -422% Viral clearance, day 7 -11% c19favipiravir.com Lou et al. Favipiravir for COVID-19 RCT LATE TREATMENT Favors favipiravir Favors control
Lou, 19 patient favipiravir late treatment RCT: 422% higher ICU admission [p=0.21] and 422% worse viral clearance [p=0.21] https://c19p.org/lou
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Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial
Lou et al., European Journal of Pharmaceutical Sciences, doi:10.1016/j.ejps.2020.105631
25 Oct 2020    Source   PDF   Share   Tweet
Small late stage RCT with 10 favipiravir, 10 baloxavir marboxil, and 10 control patients in China, showing no significant differences. ChiCTR 2000029544.
risk of ICU admission, 422.2% higher, RR 5.22, p = 0.21, treatment 2 of 9 (22.2%), control 0 of 10 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of no viral clearance, 422.2% higher, RR 5.22, p = 0.21, treatment 2 of 9 (22.2%), control 0 of 10 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 14.
risk of no viral clearance, 11.1% higher, RR 1.11, p = 1.00, treatment 5 of 9 (55.6%), control 5 of 10 (50.0%), day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lou et al., 25 Oct 2020, Randomized Controlled Trial, China, peer-reviewed, 13 authors, average treatment delay 8.5 days.
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Late treatment
is less effective
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