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Favipiravir study #21   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Improvement 88% Imp. Relative Risk, 95% CI Improvement (b) 89% Virological cure 50% Kulzhanova: Clinical efficacy of the antiviral drug favipi.. c19favipiravir.com/kulzhanova.html Favors favipiravir Favors control
8/31 Late treatment study
Kulzhanova et al., (Peer Reviewed)
Clinical efficacy of the antiviral drug favipiravir in the complex treatment of patients with COVID-19 coronavirus infection
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Retrospective 40 favipiravir patients in Kazakhstan and 40 controls, showing faster recovery and viral clearance with treatment.
risk of no improvement, 88.0% lower, RR 0.12, p < 0.001, treatment 3 of 40 (7.5%), control 25 of 40 (62.5%), mid-recovery day 7.
risk of no improvement, 88.9% lower, RR 0.11, p = 0.12, treatment 0 of 40 (0.0%), control 4 of 40 (10.0%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14.
risk of no virological cure, 50.0% lower, RR 0.50, p = 0.18, treatment 6 of 40 (15.0%), control 12 of 40 (30.0%).
Kulzhanova et al., 8/31/2021, retrospective, Kazakhstan, Asia, peer-reviewed, 10 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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