Khamis: Randomized Controlled Open Label Trial on the Use of Favipiravir Combined with Inhaled Interferon beta-1b in Hospitalized Patients with Moderate to Severe COVID-19 Pneumonia

Khamis, 89 patient favipiravir late treatment RCT: 15% lower mortality [p=1], 2% higher ICU admission [p=1], and 10% worse recovery [p=0.82] https://c19p.org/khamisf

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Randomized Controlled Open Label Trial on the Use of Favipiravir Combined with Inhaled Interferon beta-1b in Hospitalized Patients with Moderate to Severe COVID-19 Pneumonia

Khamis et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.11.008

9 Nov 2020 Source PDF Share Tweet

Small 89 patient RCT comparing favipiravir and inhaled interferon with HCQ for moderate to severe COVID-19 pneumonia, not finding significant differences. There was no control group.

risk of death, 14.8% lower, RR 0.85, p = 1.00, treatment 5 of 44 (11.4%), control 6 of 45 (13.3%), NNT 51.

risk of ICU admission, 2.3% higher, RR 1.02, p = 1.00, treatment 8 of 44 (18.2%), control 8 of 45 (17.8%).

risk of no recovery, 9.6% higher, RR 1.10, p = 0.82, treatment 15 of 44 (34.1%), control 14 of 45 (31.1%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in the after exclusion results of meta analysis: trials compares against another treatment showing significant efficacy in trials.

Khamis et al., 11/9/2020, Randomized Controlled Trial, Oman, Middle East, peer-reviewed, 11 authors, study period 22 June, 2020 - 13 August, 2020, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with interferon beta-1b) - results of individual treatments may vary.

All Studies Meta Analysis

This Paper Favipiravir All

Late treatment
is less effective

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