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Home   COVID-19 treatment studies for Favipiravir  COVID-19 treatment studies for Favipiravir  C19 studies: Favipiravir  Favipiravir   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 89% Improvement Relative Risk ER visit 30% Recovery 16% Viral shedding -32% primary c19favipiravir.com/holubar.html Favors favipiravir Favors control
24 November 2021 - Early treatment study
Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial
Holubar et al., medRxiv, doi:10.1101/2021.11.22.21266690 (Preprint)
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Small RCT 116 mITT patients in the USA, 59 treated with favipiravir, showing no significant differences with treatment.
risk of hospitalization, 89.0% lower, RR 0.11, p = 0.06, treatment 0 of 75 (0.0%), control 4 of 74 (5.4%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm). With the observed event rates, ~11 more patients per arm would result in statistical significance.
risk of ER visit, 29.5% lower, RR 0.70, p = 0.56, treatment 5 of 75 (6.7%), control 7 of 74 (9.5%), NNT 36.
risk of no recovery, 16.0% lower, RR 0.84, p = 0.43, treatment 65, control 70, initial resolution of symptoms.
viral shedding, 31.6% higher, RR 1.32, p = 0.24, treatment 59, control 57.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Holubar et al., 11/24/2021, Double Blind Randomized Controlled Trial, USA, North America, preprint, 26 authors, average treatment delay 5.0 days.
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