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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 68% Improvement Relative Risk ICU admission 35% Hospitalization time 25% Viral clearance 18% c19favipiravir.com Hassaniazad et al. IRCT20200506047323N3 Favipiravir RCT LATE Favors favipiravir Favors lopinavir/ri..
Hassaniazad, 63 patient favipiravir late treatment RCT: 68% lower mortality [p=0.15], 35% lower ICU admission [p=0.51], 25% shorter hospitalization [p=0.14], and 18% improved viral clearance [p=0.24] https://c19p.org/hassaniazad2
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Efficacy and safety of favipiravir plus interferon-beta versus lopinavir/ritonavir plus interferon-beta in moderately ill patients with COVID-19: A randomized clinical trial
Hassaniazad et al., Journal of Medical Virology, doi:10.1002/jmv.27724
24 Mar 2022    Source   PDF   Share   Tweet
RCT comparing favipiravir and lopinavir/ritonavir, showing no significant differences. All patients received interferon-beta. Favipiravir 1600mg bid for the first day and 600mg bid for the following 4 days.
risk of death, 67.7% lower, RR 0.32, p = 0.15, treatment 2 of 32 (6.2%), control 6 of 31 (19.4%), NNT 7.6, day 14.
risk of ICU admission, 35.4% lower, RR 0.65, p = 0.51, treatment 4 of 32 (12.5%), control 6 of 31 (19.4%), NNT 15, day 14.
hospitalization time, 25.0% lower, relative time 0.75, p = 0.14, treatment 32, control 31.
risk of no viral clearance, 18.0% lower, RR 0.82, p = 0.24, treatment 22 of 32 (68.8%), control 26 of 31 (83.9%), NNT 6.6, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hassaniazad et al., 3/24/2022, Randomized Controlled Trial, Iran, Middle East, peer-reviewed, mean age 53.8, 7 authors, this trial compares with another treatment - results may be better when compared to placebo, trial IRCT20200506047323N3.
Contact: m.fathalipour@yahoo.com.
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This PaperFavipiravirAll
Late treatment
is less effective
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