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0 0.5 1 1.5 2+ Mortality -42% Improvement Relative Risk ICU admission -90% Recovery time -11% c19favipiravir.com Almoosa et al. Favipiravir for COVID-19 LATE Favors favipiravir Favors control
Almoosa, 226 patient favipiravir late treatment study: 42% higher mortality [p=0.1], 90% higher ICU admission [p=0.02], and 11% slower recovery [p=0.17] https://c19p.org/almoosa
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Favipiravir versus Standard of Care in Patients with Severe COVID-19 Infections: A Retrospective Comparative Study
Almoosa et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.022
24 Aug 2021    Source   PDF   Share   Tweet
Retrospective 226 COVID-19 pneumonia patients, 110 treated with favipiravir, showing higher mortality (p=0.1) and ICU admission (p=0.02) with treatment in multivariate analysis.
risk of death, 42.3% higher, RR 1.42, p = 0.10, treatment 33 of 110 (30.0%), control 24 of 116 (20.7%), adjusted per study, odds ratio converted to relative risk, overall mortality, multivariate binary logistic regression.
risk of ICU admission, 90.0% higher, OR 1.90, p = 0.02, treatment 110, control 116, adjusted per study, multivariate binary logistic regression, RR approximated with OR.
recovery time, 10.9% higher, relative time 1.11, p = 0.17, treatment 110, control 116.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Almoosa et al., 8/24/2021, retrospective, Saudi Arabia, Middle East, peer-reviewed, 14 authors.
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Late treatment
is less effective
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