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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -42% Improvement Relative Risk ICU admission -90% Recovery time -11% c19favipiravir.com/almoosa.html Favors favipiravir Favors control
24 August 2021 - Late treatment study
Favipiravir versus Standard of Care in Patients with Severe COVID-19 Infections: A Retrospective Comparative Study
Almoosa et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.022 (Peer Reviewed)
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Retrospective 226 COVID-19 pneumonia patients, 110 treated with favipiravir, showing higher mortality (p=0.1) and ICU admission (p=0.02) with treatment in multivariate analysis.
risk of death, 42.3% higher, RR 1.42, p = 0.10, treatment 33 of 110 (30.0%), control 24 of 116 (20.7%), adjusted per study, odds ratio converted to relative risk, overall mortality, multivariate binary logistic regression.
risk of ICU admission, 90.0% higher, RR 1.90, p = 0.02, treatment 110, control 116, adjusted per study, multivariate binary logistic regression, RR approximated with OR.
recovery time, 10.9% higher, relative time 1.11, p = 0.17, treatment 110, control 116.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Almoosa et al., 8/24/2021, retrospective, Saudi Arabia, Middle East, peer-reviewed, 14 authors.
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