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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Clinical improvement -2% primary Days to clinical improvem.. -6% Viral clearance 44% c19favipiravir.com Alattar et al. Favipiravir for COVID-19 EARLY Favors favipiravir Favors control
Alattar, 774 patient favipiravir early treatment PSM study: 33% lower mortality [p=0.5], 2% worse recovery [p=0.73], and 44% improved viral clearance [p<0.0001] https://c19p.org/alattar
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Favipiravir for the Treatment of Coronavirus Disease 2019; a propensity score-matched cohort study
Alattar et al., medRxiv, doi:10.1101/2021.11.29.21267042 (Preprint)
30 Nov 2021    Source   PDF   Share   Tweet
PSM retrospective with 1,493 patients, showing significantly improved viral clearance with favipiravir. There were no significant differences in clinical improvement or mortality. Mortality was lower (2.1% vs 3.1%), without statistical significance with the small number of events.
risk of death, 33.3% lower, RR 0.67, p = 0.50, treatment 8 of 387 (2.1%), control 12 of 387 (3.1%), NNT 97, propensity score matching.
risk of no clinical improvement, 2.2% higher, RR 1.02, p = 0.73, treatment 26 of 387 (6.7%), control 28 of 387 (7.2%), NNT 194, adjusted per study, day 28, Cox proportional hazards, propensity score matching, primary outcome.
days to clinical improvement, 6.2% higher, relative time 1.06, p = 0.07, treatment 387, control 387, propensity score matching.
risk of no viral clearance, 43.9% lower, RR 0.56, p < 0.001, treatment 78 of 387 (20.2%), control 139 of 387 (35.9%), NNT 6.3, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alattar et al., 11/30/2021, retrospective, Qatar, Middle East, preprint, 25 authors, study period 23 May, 2020 - 18 July, 2020, average treatment delay 5.0 days.
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