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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -56% Improvement Relative Risk Mechanical ventilation 90% Adjusted discharge ratio 49% c19favipiravir.com/alamer.html Favors favipiravir Favors control
19 May 2021 - Late treatment study
Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis
Alamer et al., Current Medical Research and Opinion, doi:10.1080/03007995.2021.1920900 (Peer Reviewed)
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Retrospective 234 favipiravir and 223 control patients in Saudi Arabia, showing shorter time to discharge and lower progression to ventilation, but no significant difference in mortality.
risk of death, 56.0% higher, RR 1.56, p = 0.26, treatment 12 of 233 (5.2%), control 21 of 223 (9.4%), NNT 23, adjusted per study.
risk of mechanical ventilation, 90.0% lower, RR 0.10, p < 0.001, treatment 4 of 218 (1.8%), control 27 of 165 (16.4%), NNT 6.9, adjusted per study.
adjusted discharge ratio, 49.0% lower, RR 0.51, p < 0.001, treatment 221, control 201, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Alamer et al., 5/19/2021, retrospective, Saudi Arabia, Middle East, peer-reviewed, 18 authors.
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